Epic Sciences’ CTC Protein Biomarker analysis consists of:
The open 4th and 5th channel can be integrated into our base assay for CTC identification and protein biomarker characterization. These are representative images (10x) of individual CLCs detected by our N-terminal Androgen Receptor (AR) assay. Blue = DAPI, red = Cytokeratin, green = CD45, white = N-terminal AR.
Biomarker expression data can be extracted and quantitated on each individual CTC. Below is an example of biomarker analysis that looks at androgen receptor (AR) expression on cell line cells. PC3s (AR negative) and LnCAPs (AR positive) were spiked into blood and analyzed by the Epic platform for AR expression. Each individual dot on the plot represents the AR expression of an individual CTC.
Epic Sciences has developed numerous assays, which are being used to test more than 10,000 patient blood samples from clinical trial sites located in North America, Europe and Asia. These protein, FISH and genomic assays are designed to measure protein abnormalities in CTCs for 12 different cancer types.
All of Epic Sciences’ offerings can be included in your companion diagnostic assay to ensure the right treatment for the right patient at the right time. Request more information on CDx capabilities here: firstname.lastname@example.org